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Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320.
Parsy, Christophe C; Alexandre, François-René; Bidau, Valérie; Bonnaterre, Florence; Brandt, Guillaume; Caillet, Catherine; Cappelle, Sylvie; Chaves, Dominique; Convard, Thierry; Derock, Michel; Gloux, Damien; Griffon, Yann; Lallos, Lisa B; Leroy, Frederic; Liuzzi, Michel; Loi, Anna-Giulia; Moulat, Laure; Chiara, Musiu; Rahali, Houcine; Roques, Virginie; Rosinovsky, Elodie; Savin, Simon; Seifer, Maria; Standring, David; Surleraux, Dominique.
Afiliação
  • Parsy CC; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France. Electronic address: christophe.parsy@merck.com.
  • Alexandre FR; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Bidau V; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Bonnaterre F; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Brandt G; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Caillet C; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Cappelle S; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Chaves D; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Convard T; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Derock M; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Gloux D; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Griffon Y; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Lallos LB; IDENIX, a wholly-owned subsidiary of Merck & Co, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA.
  • Leroy F; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Liuzzi M; IDENIX, a wholly-owned subsidiary of Merck & Co, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA.
  • Loi AG; IDENIX, a wholly-owned subsidiary of Merck & Co, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA.
  • Moulat L; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Chiara M; IDENIX, a wholly-owned subsidiary of Merck & Co, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA.
  • Rahali H; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Roques V; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Rosinovsky E; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Savin S; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
  • Seifer M; IDENIX, a wholly-owned subsidiary of Merck & Co, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA.
  • Standring D; IDENIX, a wholly-owned subsidiary of Merck & Co, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA.
  • Surleraux D; IDENIX, a wholly-owned subsidiary of Merck & Co, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.
Bioorg Med Chem Lett ; 25(22): 5427-36, 2015 Nov 15.
Article em En | MEDLINE | ID: mdl-26410074
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas não Estruturais Virais / Hepacivirus / Compostos Macrocíclicos / Descoberta de Drogas Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas não Estruturais Virais / Hepacivirus / Compostos Macrocíclicos / Descoberta de Drogas Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article