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Cyproheptadine exhibits antitumor activity in urothelial carcinoma cells by targeting GSK3ß to suppress mTOR and ß-catenin signaling pathways.
Hsieh, Hsiao-Yen; Shen, Cheng-Huang; Lin, Ru-Inn; Feng, Yu-Min; Huang, Shih-Yuan; Wang, Yuan-Hung; Wu, Shu-Fen; Hsu, Cheng-Da; Chan, Michael W Y.
Afiliação
  • Hsieh HY; Department of Medical Research, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan; Graduate Institute of Molecular Biology, National Chung Cheng University, Min-Hsiung, Chiayi, Taiwan; Department of Life Science, National Chung Cheng University, 168 University Road, Min-Hsiung,
  • Shen CH; Department of Medical Research, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan; Department of Urology, Ditmanson Medical Foundation Chiayi Christian Hospital, 539 Jhongsiao Road, Chiayi 600, Taiwan.
  • Lin RI; Department of Radiation Oncology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan.
  • Feng YM; Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan; Department of Nursing, Chung-Jen Junior College of Nursing, Health Sciences and Management, Da-Lin, Chiayi, Taiwan.
  • Huang SY; Graduate Institute of Molecular Biology, National Chung Cheng University, Min-Hsiung, Chiayi, Taiwan; Department of Life Science, National Chung Cheng University, 168 University Road, Min-Hsiung, Chiayi, Taiwan.
  • Wang YH; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of General Surgery, Department of Urology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
  • Wu SF; Graduate Institute of Molecular Biology, National Chung Cheng University, Min-Hsiung, Chiayi, Taiwan; Department of Life Science, National Chung Cheng University, 168 University Road, Min-Hsiung, Chiayi, Taiwan.
  • Hsu CD; Department of Medical Research, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan; Graduate Institute of Molecular Biology, National Chung Cheng University, Min-Hsiung, Chiayi, Taiwan; Department of Urology, Ditmanson Medical Foundation Chiayi Christian Hospital, 539 Jhongsiao R
  • Chan MW; Graduate Institute of Molecular Biology, National Chung Cheng University, Min-Hsiung, Chiayi, Taiwan; Department of Life Science, National Chung Cheng University, 168 University Road, Min-Hsiung, Chiayi, Taiwan. Electronic address: biowyc@ccu.edu.tw.
Cancer Lett ; 370(1): 56-65, 2016 Jan 01.
Article em En | MEDLINE | ID: mdl-26454215
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Transdução de Sinais / Ciproeptadina / Quinase 3 da Glicogênio Sintase / Beta Catenina / Serina-Treonina Quinases TOR / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Transdução de Sinais / Ciproeptadina / Quinase 3 da Glicogênio Sintase / Beta Catenina / Serina-Treonina Quinases TOR / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2016 Tipo de documento: Article