The 5-HT2C receptor agonist, lorcaserin, and the 5-HT6 receptor antagonist, SB-742457, promote satiety; a microstructural analysis of feeding behaviour.
Psychopharmacology (Berl)
; 233(3): 417-24, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26507195
ABSTRACT
RATIONALE Whilst the FDA-approved anorectic, lorcaserin and various 5-hydroxytryptamine (5-HT)6 receptor antagonists reduce feeding, a direct assessment of their impact upon feeding behaviour is less clear. We therefore examined the action of lorcaserin and the clinical-stage developmental candidate 5-HT6 receptor antagonist, SB-742457, upon microstructural analysis of licking behaviour. Such analysis provides a rich source of information about the mechanisms controlling food intake. OBJECTIVES:
The objective of the present study was to gain insight into the influence upon feeding behaviour of the 5-HT2C receptor agonist, lorcaserin and the developmental 5-HT6 receptor antagonist, SB-742457.METHODS:
The impact of lorcaserin and SB-742457 upon licking behaviour of non-deprived rats for a glucose solution was assessed using microstructural analysis.RESULTS:
Lorcaserin (0.1-3.0 mg/kg) displayed a dose-dependent ability to reduce glucose consumption via reduction in the number of bouts of licking. A similar action was evident with SB-742457, but only at the lowest dose tested (3.0 mg/kg).CONCLUSIONS:
The behavioural actions of both lorcaserin and SB-742457 demonstrate they directly promote satiety.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Resposta de Saciedade
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Antagonistas da Serotonina
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Sulfonas
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Benzazepinas
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Receptores de Serotonina
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Receptor 5-HT2C de Serotonina
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Comportamento Alimentar
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Agonistas do Receptor 5-HT2 de Serotonina
Limite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Reino Unido