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Efficacy of enteral ticagrelor in hypothermic patients after out-of-hospital cardiac arrest.
Tilemann, Lisa M; Stiepak, Jan; Zelniker, Thomas; Chorianopoulos, Emanuel; Giannitsis, Evangelos; Katus, Hugo A; Müller, Oliver J; Preusch, Michael.
Afiliação
  • Tilemann LM; Department of Internal Medicine III, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
  • Stiepak J; DZHK (German Centre for Cardiovascular Research), Partner Site, Heidelberg/Mannheim, Germany.
  • Zelniker T; Department of Internal Medicine III, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
  • Chorianopoulos E; Department of Internal Medicine III, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
  • Giannitsis E; Department of Internal Medicine III, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
  • Katus HA; Department of Internal Medicine III, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
  • Müller OJ; Department of Internal Medicine III, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
  • Preusch M; DZHK (German Centre for Cardiovascular Research), Partner Site, Heidelberg/Mannheim, Germany.
Clin Res Cardiol ; 105(4): 332-40, 2016 Apr.
Article em En | MEDLINE | ID: mdl-26508414
INTRODUCTION: Delivery of crushed ticagrelor via a nasogastric tube is a widely spread off-label use in unconscious patients following out-of-hospital cardiac arrest (OHCA). Notwithstanding the importance of a potent dual antiplatelet therapy in these patients, the efficacy of crushed ticagrelor after OHCA has not been established yet. METHODS: In a prospective, single-center, observational trial, 38 consecutive MI patients after OHCA were included. 27 patients (71.1 %) underwent mild induced hypothermia. The primary outcome was platelet inhibition at 24h measured by impedance aggregometry. RESULTS: There was sufficient platelet inhibition in most patients after OHCA. In all hypothermic patients, there was an adequate platelet inhibition by ticagrelor at 24 h (p < 0.001). 15 patients (39.5 %) had significant gastroesophageal reflux and one patient with significant reflux had inadequate platelet inhibition at 24 h. There were no stent thrombosis or recurrent atherothrombotic events in these patients. CONCLUSION: Administration of crushed ticagrelor via a nasogastric tube reliably inhibited platelet function in vitro and in vivo regardless of the presence of hypothermia in MI patients. Thus, platelet inhibition can be reliably achieved in MI patients during neuroprotective hypothermia following OHCA.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Agregação Plaquetária / Adenosina / Agregação Plaquetária / Parada Cardíaca Extra-Hospitalar / Hipotermia Induzida Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Clin Res Cardiol Assunto da revista: CARDIOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Agregação Plaquetária / Adenosina / Agregação Plaquetária / Parada Cardíaca Extra-Hospitalar / Hipotermia Induzida Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Clin Res Cardiol Assunto da revista: CARDIOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha