Airway response to sirolimus therapy for the treatment of complex pediatric lymphatic malformations.
Int J Pediatr Otorhinolaryngol
; 79(12): 2466-9, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26549380
ABSTRACT
Head and neck lymphatic malformations can create airway management challenges requiring tracheotomy. Sirolimus, an inhibitor of mammalian target of rapamycin (mTOR), may inhibit growth of lymphatic malformations. We describe two patients born with large lymphatic malformations with improved airway symptoms following sirolimus therapy. Patient #1 underwent tracheotomy and multi-modal therapy including sirolimus with reduction in airway involvement but regrowth after discontinuation of sirolimus. Patient #2 also experienced a significant response to sirolimus allowing for extubation and discharge without tracheotomy. Early initiation of sirolimus therapy should be considered as a means to avoid tracheotomy in complex head and neck lymphatic malformations.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Escleroterapia
/
Sirolimo
/
Anormalidades Linfáticas
/
Imunossupressores
Tipo de estudo:
Etiology_studies
Limite:
Female
/
Humans
/
Infant
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Male
/
Newborn
Idioma:
En
Revista:
Int J Pediatr Otorhinolaryngol
Ano de publicação:
2015
Tipo de documento:
Article