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Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration.
Meredith, Erik L; Mainolfi, Nello; Poor, Stephen; Qiu, Yubin; Miranda, Karl; Powers, James; Liu, Donglei; Ma, Fupeng; Solovay, Catherine; Rao, Chang; Johnson, Leland; Ji, Nan; Artman, Gerald; Hardegger, Leo; Hanks, Shawn; Shen, Siyuan; Woolfenden, Amber; Fassbender, Elizabeth; Sivak, Jeremy M; Zhang, Yiqin; Long, Debby; Cepeda, Rosemarie; Liu, Fang; Hosagrahara, Vinayak P; Lee, Wendy; Tarsa, Peter; Anderson, Karen; Elliott, Jason; Jaffee, Bruce.
Afiliação
  • Meredith EL; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Mainolfi N; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Poor S; Ophthalmology, Novartis Institutes for BioMedical Research , 500 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Qiu Y; Ophthalmology, Novartis Institutes for BioMedical Research , 500 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Miranda K; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Powers J; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Liu D; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Ma F; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Solovay C; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Rao C; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Johnson L; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Ji N; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Artman G; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Hardegger L; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Hanks S; Ophthalmology, Novartis Institutes for BioMedical Research , 500 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Shen S; Ophthalmology, Novartis Institutes for BioMedical Research , 500 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Woolfenden A; Ophthalmology, Novartis Institutes for BioMedical Research , 500 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Fassbender E; Ophthalmology, Novartis Institutes for BioMedical Research , 500 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Sivak JM; Ophthalmology, Novartis Institutes for BioMedical Research , 500 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Zhang Y; Ophthalmology, Novartis Institutes for BioMedical Research , 500 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Long D; Ophthalmology, Novartis Institutes for BioMedical Research , 500 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Cepeda R; Ophthalmology, Novartis Institutes for BioMedical Research , 500 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Liu F; Ophthalmology, Novartis Institutes for BioMedical Research , 500 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Hosagrahara VP; Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge Massachusetts 02139, United States.
  • Lee W; Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue, Cambridge Massachusetts 02139, United States.
  • Tarsa P; Chemical and Pharmaceutical Profiling, Novartis Institutes for BioMedical Research , 500 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Anderson K; Ophthalmology, Novartis Institutes for BioMedical Research , 500 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Elliott J; Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Jaffee B; Ophthalmology, Novartis Institutes for BioMedical Research , 500 Technology Square, Cambridge, Massachusetts 02139, United States.
J Med Chem ; 58(23): 9273-86, 2015 Dec 10.
Article em En | MEDLINE | ID: mdl-26568411
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neovascularização de Coroide / Inibidores da Angiogênese / Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Inibidores de Proteínas Quinases / Degeneração Macular Exsudativa Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neovascularização de Coroide / Inibidores da Angiogênese / Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Inibidores de Proteínas Quinases / Degeneração Macular Exsudativa Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos