Suppression of abdominal aortic aneurysm formation by AR-R17779, an agonist for the &#945;7 nicotinic acetylcholine receptor.

Watanabe, Aya; Ichiki, Toshihiro; Kojima, Hiroshi; Takahara, Yusuke; Hurt-Camejo, Eva; Michaëlsson, Erik; Sankoda, Chikahiro; Ikeda, Jiro; Inoue, Eriko; Tokunou, Tomotake; Kitamoto, Shiro; Sunagawa, Kenji

Suppression of abdominal aortic aneurysm formation by AR-R17779, an agonist for the α7 nicotinic acetylcholine receptor.

Watanabe, Aya; Ichiki, Toshihiro; Kojima, Hiroshi; Takahara, Yusuke; Hurt-Camejo, Eva; Michaëlsson, Erik; Sankoda, Chikahiro; Ikeda, Jiro; Inoue, Eriko; Tokunou, Tomotake; Kitamoto, Shiro; Sunagawa, Kenji.

Afiliação

Watanabe A; Departments of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Ichiki T; Departments of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. Electronic address: ichiki@cardiol.med.kyushu-u.ac.jp.
Kojima H; Departments of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Takahara Y; Departments of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Hurt-Camejo E; Strategy Team, CVMD IMED, AstraZeneca, Mölndal, Sweden.
Michaëlsson E; Department of Bioscience, CVMD IMED, AstraZeneca, Mölndal, Sweden.
Sankoda C; Departments of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Ikeda J; Departments of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Inoue E; Departments of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Tokunou T; Departments of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Kitamoto S; Departments of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Sunagawa K; Departments of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Atherosclerosis ; 244: 113-20, 2016 Jan.

Article em En | MEDLINE | ID: mdl-26613536

Assuntos

Aneurisma da Aorta Abdominal/prevenção & controle; Hidrocarbonetos Aromáticos com Pontes/farmacologia; Compostos de Espiro/farmacologia; Receptor Nicotínico de Acetilcolina alfa7/agonistas; Animais; Aneurisma da Aorta Abdominal/genética; Aneurisma da Aorta Abdominal/metabolismo; Western Blotting; Citocinas/biossíntese; Citocinas/genética; Modelos Animais de Doenças; Progressão da Doença; Regulação da Expressão Gênica/efeitos dos fármacos; Metaloproteinases da Matriz/biossíntese; Metaloproteinases da Matriz/genética; Camundongos; Camundongos Endogâmicos C57BL; RNA/genética; Reação em Cadeia da Polimerase Via Transcriptase Reversa

Palavras-chave

Abdominal aortic aneurysm; Cytokines; Matrix metalloproteinase; α7 nicotinic acetylcholine receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Hidrocarbonetos Aromáticos com Pontes / Aneurisma da Aorta Abdominal / Receptor Nicotínico de Acetilcolina alfa7 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Atherosclerosis Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão

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