Site-selective chemical modification of chymotrypsin using peptidyl derivatives bearing optically active diphenyl 1-amino-2-phenylethylphosphonate: Stereochemical effect of the diphenyl phosphonate moiety.

Ono, Shin; Nakai, Takahiko; Kuroda, Hirofumi; Miyatake, Ryuta; Horino, Yoshikazu; Abe, Hitoshi; Umezaki, Masahito; Oyama, Hiroshi

Ono, Shin; Nakai, Takahiko; Kuroda, Hirofumi; Miyatake, Ryuta; Horino, Yoshikazu; Abe, Hitoshi; Umezaki, Masahito; Oyama, Hiroshi.

Afiliação

Ono S; Genome Biotechnology Laboratory, Kanazawa Institute of Technology, Hakusan, 924-0838, Japan.
Nakai T; Graduate School of Science and Engineering, University of Toyama, Toyama, 930-8555, Japan.
Kuroda H; Department of General Education, Ishikawa National College of Technology, Ishikawa, 929-0392, Japan.
Miyatake R; Graduate School of Science and Engineering, University of Toyama, Toyama, 930-8555, Japan.
Horino Y; Graduate School of Science and Engineering, University of Toyama, Toyama, 930-8555, Japan.
Abe H; Graduate School of Science and Engineering, University of Toyama, Toyama, 930-8555, Japan.
Umezaki M; Institute of Natural Medicine, University of Toyama, Toyama, 930-0194, Japan.
Oyama H; Faculty of Science and Engineering, Setsunan University, Osaka, 572-8508, Japan.

Biopolymers ; 106(4): 521-30, 2016 Nov 04.

Article em En | MEDLINE | ID: mdl-26615968

Assuntos

Quimotripsina/química; Dipeptídeos/química; Animais; Organofosfonatos/química

Palavras-chave

2-pyridinaldoxime methiodide; optically active diphenyl (1-aminoalkyl)phosphonate; serine protease; site-selective chemical modification; stereoselective reactivation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quimotripsina / Dipeptídeos Limite: Animals Idioma: En Revista: Biopolymers Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão

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