Nicorandil stimulates a Naâº/Ca²âº exchanger by activating guanylate cyclase in guinea pig cardiac myocytes.

Wei, Jiazhang; Watanabe, Yasuhide; Takeuchi, Kazuhiko; Yamashita, Kanna; Tashiro, Miyuki; Kita, Satomi; Iwamoto, Takahiro; Watanabe, Hiroshi; Kimura, Junko

Nicorandil stimulates a Naâº/Ca²âº exchanger by activating guanylate cyclase in guinea pig cardiac myocytes.

Wei, Jiazhang; Watanabe, Yasuhide; Takeuchi, Kazuhiko; Yamashita, Kanna; Tashiro, Miyuki; Kita, Satomi; Iwamoto, Takahiro; Watanabe, Hiroshi; Kimura, Junko.

Afiliação

Wei J; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, 431-3192, Japan.
Watanabe Y; Division of Pharmacological Science, Department of Health Science, Hamamatsu University School of Medicine, Hamamatsu, 431-3192, Japan. w-yasu@hama-med.ac.jp.
Takeuchi K; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, 431-3192, Japan.
Yamashita K; Division of Pharmacological Science, Department of Health Science, Hamamatsu University School of Medicine, Hamamatsu, 431-3192, Japan.
Tashiro M; Division of Pharmacological Science, Department of Health Science, Hamamatsu University School of Medicine, Hamamatsu, 431-3192, Japan.
Kita S; Department of Pharmacology, Faculty of Medicine, Fukuoka University, Fukuoka, 814-0180, Japan.
Iwamoto T; Department of Pharmacology, Faculty of Medicine, Fukuoka University, Fukuoka, 814-0180, Japan.
Watanabe H; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, 431-3192, Japan.
Kimura J; Department of Pharmacology, Fukushima Medical University, Fukushima, 960-1295, Japan.

Pflugers Arch ; 468(4): 693-703, 2016 Apr.

Article em En | MEDLINE | ID: mdl-26631169

Assuntos

Antiarrítmicos/farmacologia; Guanilato Ciclase/metabolismo; Miócitos Cardíacos/efeitos dos fármacos; Nicorandil/farmacologia; Trocador de Sódio e Cálcio/metabolismo; Potenciais de Ação; Animais; Cálcio/metabolismo; Linhagem Celular; Células Cultivadas; Cricetinae; Cricetulus; Cães; Cobaias; Ventrículos do Coração/citologia; Masculino; Miócitos Cardíacos/metabolismo; Miócitos Cardíacos/fisiologia

Palavras-chave

Cardiac myocytes; Cyclic GMP; KATP channel opener; Na+/Ca2+ exchange current (I NCX); Nicorandil

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trocador de Sódio e Cálcio / Nicorandil / Miócitos Cardíacos / Guanilato Ciclase / Antiarrítmicos Limite: Animals Idioma: En Revista: Pflugers Arch Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão

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