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Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies.
Zuchero, Y Joy Yu; Chen, Xiaocheng; Bien-Ly, Nga; Bumbaca, Daniela; Tong, Raymond K; Gao, Xiaoying; Zhang, Shuo; Hoyte, Kwame; Luk, Wilman; Huntley, Melanie A; Phu, Lilian; Tan, Christine; Kallop, Dara; Weimer, Robby M; Lu, Yanmei; Kirkpatrick, Donald S; Ernst, James A; Chih, Ben; Dennis, Mark S; Watts, Ryan J.
Afiliação
  • Zuchero YJ; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: joy.yu929@gmail.com.
  • Chen X; Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Bien-Ly N; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Bumbaca D; Developmental Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Tong RK; Protein Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Gao X; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Zhang S; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Hoyte K; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Luk W; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Huntley MA; Bioinformatics and Computational Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Phu L; Protein Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Tan C; Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Kallop D; Biomedical Imaging, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Weimer RM; Biomedical Imaging, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lu Y; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Kirkpatrick DS; Protein Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ernst JA; Protein Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Chih B; Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: chih.ben@gene.com.
  • Dennis MS; Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Watts RJ; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Neuron ; 89(1): 70-82, 2016 Jan 06.
Article em En | MEDLINE | ID: mdl-26687840
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transporte Biológico / Receptores da Transferrina / Encéfalo / Barreira Hematoencefálica / Anticorpos Limite: Animals Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transporte Biológico / Receptores da Transferrina / Encéfalo / Barreira Hematoencefálica / Anticorpos Limite: Animals Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2016 Tipo de documento: Article