Synthetic Entries to and Biological Activity of Pyrrolopyrimidines.
Chem Rev
; 116(1): 80-139, 2016 Jan 13.
Article
em En
| MEDLINE
| ID: mdl-26699634
ABSTRACT
This review summarizes recent literature (2000-2015) on the synthesis and pharmaceutical properties of pyrrolopyrimidines. These modified pyrimidine bases, fused to a pyrrole ring, and their corresponding nucleosides display a broad applicability in medicinal chemistry. This overview is divided into three main sections, according to the respective isomers pyrrolo[2,3-d]pyrimidines, pyrrolo[3,2-d]pyrimidines, and pyrrolo[3,4-d]pyrimidines. Each section contains a description of common retro-synthetic strategies, with particular attention for newly reported synthetic entries to the scaffold. Next, the synthetic strategies and the ways in which the scaffolds can be further modified are exemplified according to the biological properties of the obtained products.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Pirróis
/
Descoberta de Drogas
/
Técnicas de Química Sintética
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chem Rev
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Bélgica