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Intralesional cryosurgery for the treatment of basal cell carcinoma of the lower extremities in elderly subjects: a feasibility study.
Har-Shai, Yaron; Sommer, Adir; Gil, Tamir; Krausz, Judit; Gal-Or, Nir; Mettanes, Issa; Lavi, Idit; Eyal, Nir; Brizgalin, Leonid; Taran, Amir; Har-Shai, Lior; Elmalach, Irit.
Afiliação
  • Har-Shai Y; Unit of Plastic Surgery, Carmel Medical Center, Haifa, Israel.
  • Sommer A; Bruce Rappaport Faculty of Medicine, Israel Institute of Technology (Technion), Haifa, Israel.
  • Gil T; Bruce Rappaport Faculty of Medicine, Israel Institute of Technology (Technion), Haifa, Israel.
  • Krausz J; Unit of Plastic Surgery, Carmel Medical Center, Haifa, Israel.
  • Gal-Or N; Bruce Rappaport Faculty of Medicine, Israel Institute of Technology (Technion), Haifa, Israel.
  • Mettanes I; Department of Pathology, Ha-Emek Medical Center, Afula, Israel.
  • Lavi I; Bruce Rappaport Faculty of Medicine, Israel Institute of Technology (Technion), Haifa, Israel.
  • Eyal N; Unit of Plastic Surgery, Carmel Medical Center, Haifa, Israel.
  • Brizgalin L; Bruce Rappaport Faculty of Medicine, Israel Institute of Technology (Technion), Haifa, Israel.
  • Taran A; Unit of Plastic Surgery, Carmel Medical Center, Haifa, Israel.
  • Har-Shai L; Bruce Rappaport Faculty of Medicine, Israel Institute of Technology (Technion), Haifa, Israel.
  • Elmalach I; Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel.
Int J Dermatol ; 55(3): 342-50, 2016 Mar.
Article em En | MEDLINE | ID: mdl-26749491
ABSTRACT

BACKGROUND:

Incidences of basal cell carcinoma (BCC) on the lower extremities in elderly patients are rising. Surgical approaches to the treatment of BCC are subject to possible difficulties in healing, failure of skin grafts, and wound infection. This study assessed the efficacy of intralesional cryosurgery in the treatment of BCC of the lower limbs in elderly patients.

METHODS:

This study included eight patients aged >60 years in whom a total of 10 nodular or superficial BCCs of the lower limbs were confirmed by biopsy. The patients' medical histories revealed comorbidities including hypertension, diabetes, hypercholesterolemia, venous insufficiency, and deep vein thrombosis of the legs, congestive heart failure, chronic renal failure, and ischemic heart disease. Using liquid nitrogen, an intralesional cryosurgery needle (CryoShape) was inserted into the tumor to facilitate its complete freezing. Treatment success was confirmed by biopsy taken approximately 3 months after complete healing of the cryo-wound.

RESULTS:

The average size of the lesions treated was 2.49 cm(2) (16.4 × 15.2 mm). Mean recovery time was 79.9 days. Biopsies were obtained at a mean of 85.3 days after the wound had healed. All 10 biopsies verified the complete destruction of the tumor. There was no evidence of wound infection or tumor recurrence over a follow-up period of 28 months.

CONCLUSIONS:

This study demonstrates that a single intralesional cryosurgery session can completely eradicate BCC on the lower extremities in elderly patients. This technique is associated with relatively minor complications, is well tolerated, and represents a safe and effective therapeutic modality for BCC of the lower limbs.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Neoplasias Cutâneas / Carcinoma Basocelular / Criocirurgia Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Int J Dermatol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Israel

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Neoplasias Cutâneas / Carcinoma Basocelular / Criocirurgia Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Int J Dermatol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Israel