An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor.
Elife
; 52016 Jan 14.
Article
em En
| MEDLINE
| ID: mdl-26765567
ABSTRACT
Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças das Plantas
/
Proteínas de Plantas
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Autofagia
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Solanum tuberosum
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Proteínas Fúngicas
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Interações Hospedeiro-Patógeno
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Phytophthora infestans
Idioma:
En
Revista:
Elife
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Reino Unido