[Role of soluble receptor ST2 measurment in diagnosis and prognostic stratification in patients with heart failure]. / Význam stanovení solubilního receptoru ST2 v diagnostice a prognostické stratifikaci pacientu se srdecním selháním.

ABSTRACT

ST2 is a member of the interleukin 1 (IL1) receptor family and consists of a trans-membrane ligand (STL2) and a soluble form (sST2). sST2 is released from cardiomyocytes and fibroblasts after mechanical strain and has been identified as a novel biomarker of cardiac stress, fibrosis and remodelling. Many studies showed that sST2 brings important prognostic information in patients with heart failure. Elevated sST2 concentrations predicted risk of hospitalization and mortality independently on natriuretic peptides levels and on other clinical variables. Some stu-dies showed diagnostic role of sST2 u patients with heart failure and normal ejection fraction.