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Arabinoxylan from Mucilage of Tomatoes (Solanum lycopersicum L.): Structure and Antinociceptive Effect in Mouse Models.
do Nascimento, Georgia Erdmann; Baggio, Cristiane H; Werner, Maria Fernanda de Paula; Iacomini, Marcello; Cordeiro, Lucimara M C.
Afiliação
  • do Nascimento GE; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná , CP 19.046, CEP 81.531-980 Curitiba, PR, Brazil.
  • Baggio CH; Departamento de Farmacologia, Universidade Federal do Paraná , CEP 81.531-980 Curitiba, PR, Brazil.
  • Werner MF; Departamento de Farmacologia, Universidade Federal do Paraná , CEP 81.531-980 Curitiba, PR, Brazil.
  • Iacomini M; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná , CP 19.046, CEP 81.531-980 Curitiba, PR, Brazil.
  • Cordeiro LM; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná , CP 19.046, CEP 81.531-980 Curitiba, PR, Brazil.
J Agric Food Chem ; 64(6): 1239-44, 2016 Feb 17.
Article em En | MEDLINE | ID: mdl-26824871
Tomato is a known functional food due to its content of bioactive compounds. Herein, polysaccharides were extracted from mucilage of tomatoes, and a purified fraction (PTOK) was analyzed by sugar composition, methylation, and NMR spectroscopy analysis. The results showed the presence of an arabinoxylan, having (1→4)-linked ß-d-Xylp units in the main chain, which carried a low proportion of branching (∼5.6%), at O-2 and O-3 position, with side chains constituted by single Araf or Xylp units. Intraperitoneal administration of the arabinoxylan in mice significantly reduced the number of abdominal constrictions induced by 0.6% acetic acid and the inflammatory phase of nociception induced by 2.5% formalin, indicating that it had an antinociceptive effect on inflammatory pain models, amplifying the biological role displayed by arabinoxylans in the diet. Furthermore, this study reports the presence of an arabinoxylan in a dicotyledon plant, and also it is the first study of polysaccharides from mucilage of tomatoes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Polissacarídeos / Xilanos / Extratos Vegetais / Solanum lycopersicum / Analgésicos Limite: Animals / Humans Idioma: En Revista: J Agric Food Chem Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Polissacarídeos / Xilanos / Extratos Vegetais / Solanum lycopersicum / Analgésicos Limite: Animals / Humans Idioma: En Revista: J Agric Food Chem Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil