Effect of sex in the MRMT-1 model of cancer-induced bone pain.
F1000Res
; 4: 445, 2015.
Article
em En
| MEDLINE
| ID: mdl-26834983
ABSTRACT
An overwhelming amount of evidence demonstrates sex-induced variation in pain processing, and has thus increased the focus on sex as an essential parameter for optimization of in vivo models in pain research. Mammary cancer cells are often used to model metastatic bone pain in vivo, and are commonly used in both males and females. Here we demonstrate that compared to male rats, female rats have an increased capacity for recovery following inoculation of MRMT-1 mammary cells, thus potentially causing a sex-dependent bias in interpretation of the data.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
F1000Res
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Dinamarca