Optimum dose of neostigmine to reverse shallow neuromuscular blockade with rocuronium and cisatracurium.
Anaesthesia
; 71(4): 443-9, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26874258
ABSTRACT
We examined the use of neostigmine for reversing shallow (defined as train-of-four ratio of 0.5), cisatracurium- and rocuronium-induced neuromuscular block in 112 patients, by use of 0 µg.kg(-1) , 10 µg.kg(-1) , 20 µg.kg(-1) or 40 µg.kg(-1) dose of neostigmine for reversal. The times from neostigmine administration to train-of-four ratios of 0.7, 0.9 and 1.0 were evaluated. Analysis of variance showed that the duration of action was significantly longer after cisatracurium compared with rocuronium. The time to reach a train-of-four ratio of 1.0 was significantly shorter with neostigmine 40 µg.kg(-1) compared with lower neostigmine doses, and at this dose the time did not differ between cisatracurium and rocuronium. The recovery time from a train-of-four ratio of 0.5-1.0 did not differ between cisatracurium and rocuronium, and was significantly shortened by the administration of neostigmine. We conclude that a neostigmine dose of 40 µg.kg(-1) was the most effective at reducing recovery time after neuromuscular blockade.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Atracúrio
/
Período de Recuperação da Anestesia
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Inibidores da Colinesterase
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Bloqueio Neuromuscular
/
Androstanóis
/
Neostigmina
Tipo de estudo:
Clinical_trials
Limite:
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Anaesthesia
Ano de publicação:
2016
Tipo de documento:
Article