Prediction of early kidney transplant rejection by a crossmatch with donor skin.
Transplantation
; 48(6): 951-2, 1989 Dec.
Article
em En
| MEDLINE
| ID: mdl-2688207
ABSTRACT
Immunofluorescence staining of donor skin with recipient serum was performed in 25 patients undergoing kidney transplantation. Transplants were performed when cytotoxicity T cell crossmatches with long incubation and with antiglobulin enhancement were negative. In 20 patients the skin crossmatch was negative and all had an uneventful course. In 5 other recipients, the crossmatch with skin was positive and all developed severe rejection 1-8 days after transplantation. The correlation between skin crossmatch and early rejection was statistically highly significant (P less than 0.00001). Rejection in the skin-crossmatch-positive group led to graft loss in 3, and chronic rejection with poor residual function in the other 2 patients. Serum creatinine at one month was in the 2.6-5.0 mg/dl range in these two patients, while in the group with negative skin crossmatches 15 had serum creatinine levels of less than 1.6, and 5 were in the 1.6-2.5 mg/dl range. Although the nature of the skin antigen is unknown, it appears that this crossmatch procedure was highly accurate in predicting early kidney transplant rejection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Teste de Histocompatibilidade
/
Transplante de Rim
/
Rejeição de Enxerto
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Transplantation
Ano de publicação:
1989
Tipo de documento:
Article