Uncharged nucleoside inhibitors of ß-1,4-galactosyltransferase with activity in cells.
Chem Commun (Camb)
; 52(20): 3955-8, 2016 Mar 11.
Article
em En
| MEDLINE
| ID: mdl-26882174
ABSTRACT
We report 5-substituted uridine derivatives as novel, uncharged inhibitors of ß-1,4-galactosyltransferase and chemical tools for cellular applications. The new inhibitors reduce P-selectin glycoprotein 1 (PSGL-1) expression in human monocytes. Our results also provide novel insights into a unique mode of glycosyltransferase inhibition.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Uridina
/
Inibidores Enzimáticos
/
Galactosiltransferases
Limite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Reino Unido