Variation in KRAS driver substitution distributions between tumor types is determined by both mutation and natural selection.

Ostrow, Sheli L; Simon, Einav; Prinz, Elad; Bick, Tova; Shentzer, Talia; Nagawkar, Sima S; Sabo, Edmond; Ben-Izhak, Ofer; Hershberg, Ruth; Hershkovitz, Dov

Ostrow, Sheli L; Simon, Einav; Prinz, Elad; Bick, Tova; Shentzer, Talia; Nagawkar, Sima S; Sabo, Edmond; Ben-Izhak, Ofer; Hershberg, Ruth; Hershkovitz, Dov.

Afiliação

Ostrow SL; TICC, Technion Integrative Cancer Center at the Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Simon E; Department of Genetics and Developmental Biology, the Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Prinz E; Department of Pathology, Rambam Health Care Campus, Haifa, Israel.
Bick T; TICC, Technion Integrative Cancer Center at the Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Shentzer T; Department of Pathology, Rambam Health Care Campus, Haifa, Israel.
Nagawkar SS; Institute of Oncology, Rambam Health Care Campus, Haifa, Israel.
Sabo E; TICC, Technion Integrative Cancer Center at the Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Ben-Izhak O; TICC, Technion Integrative Cancer Center at the Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Hershberg R; Department of Pathology, Rambam Health Care Campus, Haifa, Israel.
Hershkovitz D; TICC, Technion Integrative Cancer Center at the Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Sci Rep ; 6: 21927, 2016 Feb 23.

Article em En | MEDLINE | ID: mdl-26902163

Assuntos

Adenocarcinoma/genética; Neoplasias do Colo/genética; Neoplasias Pulmonares/genética; Taxa de Mutação; Neoplasias Pancreáticas/genética; Proteínas Proto-Oncogênicas p21(ras)/genética; Adenocarcinoma/patologia; Substituição de Aminoácidos; Códon; Neoplasias do Colo/patologia; Expressão Gênica; Humanos; Neoplasias Pulmonares/patologia; Especificidade de Órgãos; Neoplasias Pancreáticas/patologia; Polimorfismo Genético; Fatores de Risco; Seleção Genética; Fumar/genética; Fumar/fisiopatologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Proteínas Proto-Oncogênicas p21(ras) / Neoplasias do Colo / Taxa de Mutação / Neoplasias Pulmonares Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Israel

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