Variations in MHC Class II Antigen Processing and Presentation in Health and Disease.
Annu Rev Immunol
; 34: 265-97, 2016 05 20.
Article
em En
| MEDLINE
| ID: mdl-26907214
ABSTRACT
MHC class II (MHC-II) molecules are critical in the control of many immune responses. They are also involved in most autoimmune diseases and other pathologies. Here, we describe the biology of MHC-II and MHC-II variations that affect immune responses. We discuss the classic cell biology of MHC-II and various perturbations. Proteolysis is a major process in the biology of MHC-II, and we describe the various components forming and controlling this endosomal proteolytic machinery. This process ultimately determines the MHC-II-presented peptidome, including cryptic peptides, modified peptides, and other peptides that are relevant in autoimmune responses. MHC-II also variable in expression, glycosylation, and turnover. We illustrate that MHC-II is variable not only in amino acids (polymorphic) but also in its biology, with consequences for both health and disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endossomos
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Antígenos de Histocompatibilidade Classe II
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Apresentação de Antígeno
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Doenças do Sistema Imunitário
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Antígenos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Annu Rev Immunol
Ano de publicação:
2016
Tipo de documento:
Article