Safety profile of anakinra in the management of rheumatologic, metabolic and autoinflammatory disorders.
Clin Exp Rheumatol
; 34(3): 531-8, 2016.
Article
em En
| MEDLINE
| ID: mdl-26940286
ABSTRACT
Anakinra is a biologic response modifier that competitively antagonises the biologic effects of interleukin-1, the ancestor pleiotropic proinflammatory cytokine produced by numerous cell types, found in excess in the serum, synovial fluid and any involved tissues of patients with many inflammatory diseases. The magnitude of the risk of different infections, including Mycobacterium tuberculosis (Mtb) infection, associated with the large use of anakinra in many rheumatologic, metabolic or autoinflammatory disorders is still unknown. In addition, it is unclear whether this effect is modified by the concomitant use of antirheumatic drugs and corticosteroids. The rates of development of Mtb disease in patients treated with anakinra due to rheumatoid arthritis, systemic autoinflammatory diseases, Schnitzler's syndrome, Behçet's disease, adult-onset Still disease, systemic juvenile idiopathic arthritis, gout and diabetes mellitus have been usually very low. However, clinicians must carefully weigh the benefits of biological drugs against their risks, particularly in patients prone to infections. Additional data are needed to understand whether this risk of Mtb infection and reactivation are representative of a class effect related to biologics or whether anakinra bears specifically an intrinsic lower risk in comparison with other biologic drugs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Reumáticas
/
Proteína Antagonista do Receptor de Interleucina 1
/
Doenças do Sistema Imunitário
/
Doenças Metabólicas
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Clin Exp Rheumatol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Itália