Strategies toward optimization of the metabolism of a series of serotonin-4 partial agonists: investigation of azetidines as piperidine isosteres.

Obach, Ronald Scott; LaChapelle, Erik A; Brodney, Michael A; Vanase-Frawley, Michelle; Kauffman, Gregory W; Sawant-Basak, Aarti

Obach, Ronald Scott; LaChapelle, Erik A; Brodney, Michael A; Vanase-Frawley, Michelle; Kauffman, Gregory W; Sawant-Basak, Aarti.

Afiliação

Obach RS; a Department of Pharmacokinetics , Dynamics, and Metabolism , Groton , CT , USA.
LaChapelle EA; b Department of Neuroscience Chemistry , Groton , CT , USA.
Brodney MA; c Department of Neuroscience Medicinal Chemistry , Cambridge , MA , USA , and.
Vanase-Frawley M; a Department of Pharmacokinetics , Dynamics, and Metabolism , Groton , CT , USA.
Kauffman GW; a Department of Pharmacokinetics , Dynamics, and Metabolism , Groton , CT , USA.
Sawant-Basak A; d Department of Pharmacokinetics , Dynamics, and Metabolism , Cambridge , MA , USA.

Xenobiotica ; 46(12): 1112-1121, 2016 Dec.

Article em En | MEDLINE | ID: mdl-26947511

Assuntos

Azetidinas/farmacologia; Piperidinas/farmacologia; Serotonina/metabolismo; Azetidinas/metabolismo; Humanos; Piperidinas/metabolismo

Palavras-chave

Alicyclic amine; azetidine; metabolism; piperidine

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Azetidinas / Serotonina Limite: Humans Idioma: En Revista: Xenobiotica Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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