Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects.

Gautam, Raju; Singh, Manjari; Gautam, Swetlana; Rawat, Jitendra Kumar; Saraf, Shubhini A; Kaithwas, Gaurav

Gautam, Raju; Singh, Manjari; Gautam, Swetlana; Rawat, Jitendra Kumar; Saraf, Shubhini A; Kaithwas, Gaurav.

Afiliação

Gautam R; Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University, VidyaVihar, Raebareli Road, Lucknow, 226 025, U. P, India.
Singh M; Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University, VidyaVihar, Raebareli Road, Lucknow, 226 025, U. P, India.
Gautam S; Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University, VidyaVihar, Raebareli Road, Lucknow, 226 025, U. P, India.
Rawat JK; Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University, VidyaVihar, Raebareli Road, Lucknow, 226 025, U. P, India.
Saraf SA; Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University, VidyaVihar, Raebareli Road, Lucknow, 226 025, U. P, India.
Kaithwas G; Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University, VidyaVihar, Raebareli Road, Lucknow, 226 025, U. P, India. gauravpharm@hotmail.com.

BMC Complement Altern Med ; 16: 99, 2016 Mar 10.

Article em En | MEDLINE | ID: mdl-26965456

Assuntos

Anti-Inflamatórios/uso terapêutico; Antioxidantes/uso terapêutico; Intestinos/efeitos dos fármacos; Metotrexato/efeitos adversos; Fitoterapia; Extratos Vegetais/uso terapêutico; Rutina/uso terapêutico; Ácidos/metabolismo; Animais; Anti-Inflamatórios/farmacologia; Antimetabólitos Antineoplásicos/efeitos adversos; Antioxidantes/farmacologia; Araquidonato 15-Lipoxigenase/metabolismo; Citocinas/metabolismo; Inflamação/prevenção & controle; Enteropatias/metabolismo; Enteropatias/prevenção & controle; Intestinos/patologia; Estresse Oxidativo/efeitos dos fármacos; Extratos Vegetais/farmacologia; Prostaglandina-Endoperóxido Sintases/metabolismo; Ratos Wistar; Rutina/farmacologia

Palavras-chave

Antioxidant; Cyclooxygenase; Cytokines; Immunoregulatory; Lipoxygenase; Proinflammatory

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rutina / Extratos Vegetais / Metotrexato / Intestinos / Fitoterapia / Anti-Inflamatórios / Antioxidantes Limite: Animals Idioma: En Revista: BMC Complement Altern Med Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Índia

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