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Meta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene.
Ludwig, Kerstin U; Ahmed, Syeda Tasnim; Böhmer, Anne C; Sangani, Nasim Bahram; Varghese, Sheryil; Klamt, Johanna; Schuenke, Hannah; Gültepe, Pinar; Hofmann, Andrea; Rubini, Michele; Aldhorae, Khalid Ahmed; Steegers-Theunissen, Regine P; Rojas-Martinez, Augusto; Reiter, Rudolf; Borck, Guntram; Knapp, Michael; Nakatomi, Mitsushiro; Graf, Daniel; Mangold, Elisabeth; Peters, Heiko.
Afiliação
  • Ludwig KU; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Ahmed ST; Department of Genomics, Life&Brain Center, University of Bonn, Bonn, Germany.
  • Böhmer AC; Institute of Genetic Medicine, Newcastle University, International Centre for Life, Newcastle upon Tyne, United Kingdom.
  • Sangani NB; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Varghese S; Department of Genomics, Life&Brain Center, University of Bonn, Bonn, Germany.
  • Klamt J; Institute of Genetic Medicine, Newcastle University, International Centre for Life, Newcastle upon Tyne, United Kingdom.
  • Schuenke H; Institute of Genetic Medicine, Newcastle University, International Centre for Life, Newcastle upon Tyne, United Kingdom.
  • Gültepe P; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Hofmann A; Department of Genomics, Life&Brain Center, University of Bonn, Bonn, Germany.
  • Rubini M; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Aldhorae KA; Department of Genomics, Life&Brain Center, University of Bonn, Bonn, Germany.
  • Steegers-Theunissen RP; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Rojas-Martinez A; Department of Genomics, Life&Brain Center, University of Bonn, Bonn, Germany.
  • Reiter R; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Borck G; Department of Genomics, Life&Brain Center, University of Bonn, Bonn, Germany.
  • Knapp M; Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Italy.
  • Nakatomi M; Orthodontic Department, College of Dentistry, Thamar University, Thamar, Yemen.
  • Graf D; Department of Obstetrics and Gynaecology, ErasmusMC, Rotterdam, Netherlands.
  • Mangold E; Department of Epidemiology, Radboud University Medical Center, Nijmegen, Netherlands.
  • Peters H; Department of Biochemistry and Molecular Medicine, School of Medicine, and Centro de Investigación y Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.
PLoS Genet ; 12(3): e1005914, 2016 Mar.
Article em En | MEDLINE | ID: mdl-26968009
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Fenda Labial / Fissura Palatina / Predisposição Genética para Doença / Peptídeos e Proteínas de Sinalização Intercelular / Estudo de Associação Genômica Ampla Tipo de estudo: Etiology_studies / Prognostic_studies / Systematic_reviews Limite: Animals / Humans Idioma: En Revista: PLoS Genet Assunto da revista: GENETICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Fenda Labial / Fissura Palatina / Predisposição Genética para Doença / Peptídeos e Proteínas de Sinalização Intercelular / Estudo de Associação Genômica Ampla Tipo de estudo: Etiology_studies / Prognostic_studies / Systematic_reviews Limite: Animals / Humans Idioma: En Revista: PLoS Genet Assunto da revista: GENETICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha