Amelioration of Diabetic Mouse Nephropathy by Catalpol Correlates with Down-Regulation of Grb10 Expression and Activation of Insulin-Like Growth Factor 1 / Insulin-Like Growth Factor 1 Receptor Signaling.

Yang, Shasha; Deng, Huacong; Zhang, Qunzhou; Xie, Jing; Zeng, Hui; Jin, Xiaolong; Ling, Zixi; Shan, Qiaoyun; Liu, Momo; Ma, Yuefei; Tang, Juan; Wei, Qianping

Yang, Shasha; Deng, Huacong; Zhang, Qunzhou; Xie, Jing; Zeng, Hui; Jin, Xiaolong; Ling, Zixi; Shan, Qiaoyun; Liu, Momo; Ma, Yuefei; Tang, Juan; Wei, Qianping.

Afiliação

Yang S; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Deng H; Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhang Q; Department of Oral Surgery and Pharmacology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Xie J; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zeng H; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jin X; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ling Z; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Shan Q; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liu M; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ma Y; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Tang J; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wei Q; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

PLoS One ; 11(3): e0151857, 2016.

Article em En | MEDLINE | ID: mdl-26986757

Assuntos

Nefropatias Diabéticas/tratamento farmacológico; Medicamentos de Ervas Chinesas/uso terapêutico; Proteína Adaptadora GRB10/fisiologia; Hipoglicemiantes/uso terapêutico; Fator de Crescimento Insulin-Like I/fisiologia; Glucosídeos Iridoides/uso terapêutico; Receptor IGF Tipo 1/fisiologia; Animais; Western Blotting; Diabetes Mellitus Experimental/complicações; Nefropatias Diabéticas/metabolismo; Nefropatias Diabéticas/fisiopatologia; Modelos Animais de Doenças; Regulação para Baixo/efeitos dos fármacos; Medicamentos de Ervas Chinesas/farmacologia; Proteína Adaptadora GRB10/biossíntese; Expressão Gênica/efeitos dos fármacos; Expressão Gênica/fisiologia; Hipoglicemiantes/farmacologia; Fator de Crescimento Insulin-Like I/metabolismo; Glucosídeos Iridoides/farmacologia; Rim/efeitos dos fármacos; Rim/metabolismo; Rim/fisiopatologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Reação em Cadeia da Polimerase; Receptor IGF Tipo 1/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like I / Medicamentos de Ervas Chinesas / Receptor IGF Tipo 1 / Nefropatias Diabéticas / Proteína Adaptadora GRB10 / Glucosídeos Iridoides / Hipoglicemiantes Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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