Curcumin enhances human macrophage control of Mycobacterium tuberculosis infection.
Respirology
; 21(5): 951-7, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-27012592
ABSTRACT
BACKGROUND AND OBJECTIVE:
With the worldwide emergence of highly drug-resistant tuberculosis (TB), novel agents that have direct antimycobacterial effects or that enhance host immunity are urgently needed. Curcumin is a polyphenol responsible for the bright yellow-orange colour of turmeric, a spice derived from the root of the perennial herb Curcuma longa. Curcumin is a potent inducer of apoptosis-an effector mechanism used by macrophages to kill intracellular Mycobacterium tuberculosis (MTB).METHODS:
An in vitro human macrophage infection model was used to determine the effects of curcumin on MTB survival.RESULTS:
We found that curcumin enhanced the clearance of MTB in differentiated THP-1 human monocytes and in primary human alveolar macrophages. We also found that curcumin was an inducer of caspase-3-dependent apoptosis and autophagy. Curcumin mediated these anti-MTB cellular functions, in part, via inhibition of nuclear factor-kappa B (NFκB) activation.CONCLUSION:
Curcumin protects against MTB infection in human macrophages. The host-protective role of curcumin against MTB in macrophages needs confirmation in an animal model; if validated, the immunomodulatory anti-TB effects of curcumin would be less prone to drug resistance development.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Macrófagos Alveolares
/
Apoptose
/
Curcumina
/
Mycobacterium tuberculosis
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Respirology
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos