Production of Influenza Virus HA1 Harboring Native-Like Epitopes by Pichia pastoris.

Lin, Qingshan; Yang, Kunyu; He, Fangping; Jiang, Jie; Li, Tingting; Chen, Zhenqin; Li, Rui; Chen, Yixin; Li, Shaowei; Zhao, Qinjian; Xia, Ningshao

Lin, Qingshan; Yang, Kunyu; He, Fangping; Jiang, Jie; Li, Tingting; Chen, Zhenqin; Li, Rui; Chen, Yixin; Li, Shaowei; Zhao, Qinjian; Xia, Ningshao.

Afiliação

Lin Q; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361002, People's Republic of China.
Yang K; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361002, People's Republic of China.
He F; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361002, People's Republic of China.
Jiang J; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361002, People's Republic of China.
Li T; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361002, People's Republic of China.
Chen Z; National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health, Xiamen University, Xiamen, Fujian, 361002, People's Republic of China.
Li R; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361002, People's Republic of China.
Chen Y; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361002, People's Republic of China.
Li S; National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health, Xiamen University, Xiamen, Fujian, 361002, People's Republic of China.
Zhao Q; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361002, People's Republic of China. shaowei@xmu.edu.cn.
Xia N; National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health, Xiamen University, Xiamen, Fujian, 361002, People's Republic of China. shaowei@xmu.edu.cn.

Appl Biochem Biotechnol ; 179(7): 1275-89, 2016 Aug.

Article em En | MEDLINE | ID: mdl-27040529

Assuntos

Betainfluenzavirus/genética; Epitopos/biossíntese; Glicoproteínas de Hemaglutininação de Vírus da Influenza/biossíntese; Influenza Humana/imunologia; Animais; Anticorpos Antivirais/genética; Epitopos/genética; Epitopos/imunologia; Testes de Inibição da Hemaglutinação; Glicoproteínas de Hemaglutininação de Vírus da Influenza/genética; Glicoproteínas de Hemaglutininação de Vírus da Influenza/imunologia; Humanos; Vacinas contra Influenza/biossíntese; Vacinas contra Influenza/genética; Vacinas contra Influenza/imunologia; Influenza Humana/genética; Influenza Humana/prevenção & controle; Betainfluenzavirus/imunologia; Betainfluenzavirus/patogenicidade; Camundongos; Pichia/genética; Proteínas Recombinantes/biossíntese; Proteínas Recombinantes/genética; Vacinas Sintéticas/biossíntese; Vacinas Sintéticas/genética

Palavras-chave

Fed-batch fermentation; Hemagglutinin; Monoclonal antibody; Native epitopes; Pichia pastoris

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Hemaglutininação de Vírus da Influenza / Betainfluenzavirus / Influenza Humana / Epitopos Limite: Animals / Humans Idioma: En Revista: Appl Biochem Biotechnol Ano de publicação: 2016 Tipo de documento: Article

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