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Safety, tolerability, and preliminary activity of CUDC-907, a first-in-class, oral, dual inhibitor of HDAC and PI3K, in patients with relapsed or refractory lymphoma or multiple myeloma: an open-label, dose-escalation, phase 1 trial.
Younes, Anas; Berdeja, Jesus G; Patel, Manish R; Flinn, Ian; Gerecitano, John F; Neelapu, Sattva S; Kelly, Kevin R; Copeland, Amanda R; Akins, Amy; Clancy, Myles S; Gong, Lucy; Wang, Jing; Ma, Anna; Viner, Jaye L; Oki, Yasuhiro.
Afiliação
  • Younes A; Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: younesa@mskcc.org.
  • Berdeja JG; Sarah Cannon Research Institute, Nashville, TN, USA.
  • Patel MR; Sarah Cannon Research Institute, Nashville, TN, USA; Florida Cancer Specialists, Sarasota, FL, USA.
  • Flinn I; Sarah Cannon Research Institute, Nashville, TN, USA.
  • Gerecitano JF; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Neelapu SS; Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Kelly KR; Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, University of Southern California, Los Angeles, CA, USA.
  • Copeland AR; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Akins A; Sarah Cannon Research Institute, Nashville, TN, USA.
  • Clancy MS; Curis, Inc, Lexington, MA, USA.
  • Gong L; Curis, Inc, Lexington, MA, USA.
  • Wang J; Curis, Inc, Lexington, MA, USA.
  • Ma A; Curis, Inc, Lexington, MA, USA.
  • Viner JL; Curis, Inc, Lexington, MA, USA.
  • Oki Y; Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lancet Oncol ; 17(5): 622-31, 2016 05.
Article em En | MEDLINE | ID: mdl-27049457
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Morfolinas / Inibidores de Histona Desacetilases / Linfoma / Mieloma Múltiplo Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Morfolinas / Inibidores de Histona Desacetilases / Linfoma / Mieloma Múltiplo Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article