Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca²âº handling in smooth muscle cells.

Ma, Yu-Guang; Zhang, Yin-Bin; Bai, Yun-Gang; Dai, Zhi-Jun; Liang, Liang; Liu, Mei; Xie, Man-Jiang; Guan, Hai-Tao

Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca²âº handling in smooth muscle cells.

Ma, Yu-Guang; Zhang, Yin-Bin; Bai, Yun-Gang; Dai, Zhi-Jun; Liang, Liang; Liu, Mei; Xie, Man-Jiang; Guan, Hai-Tao.

Afiliação

Ma YG; Department of Oncology, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Zhang YB; Department of Oncology, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Bai YG; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.
Dai ZJ; Department of Oncology, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Liang L; Department of Oncology, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Liu M; Department of Oncology, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Xie MJ; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China. manjiangxie@hotmail.com.
Guan HT; Department of Oncology, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China. guanhaitao@cscoorg.cn.

Cardiovasc Diabetol ; 15: 63, 2016 Apr 12.

Article em En | MEDLINE | ID: mdl-27067643

Assuntos

Berberina/farmacologia; Cálcio/metabolismo; Diabetes Mellitus Experimental/tratamento farmacológico; Músculo Liso Vascular/efeitos dos fármacos; Miócitos de Músculo Liso/efeitos dos fármacos; Animais; Glicemia/efeitos dos fármacos; Glicemia/metabolismo; Canais de Cálcio Tipo L/efeitos dos fármacos; Canais de Cálcio Tipo L/metabolismo; Diabetes Mellitus Experimental/metabolismo; Dieta Hiperlipídica; Hiperglicemia/tratamento farmacológico; Hiperglicemia/metabolismo; Masculino; Miócitos de Músculo Liso/metabolismo; Ratos Sprague-Dawley

Palavras-chave

Berberine; Ca2+ releases; Contractile function; L-type Ca2+ channel (CaL); Vascular smooth muscle cells (VSMCs)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Berberina / Cálcio / Miócitos de Músculo Liso / Diabetes Mellitus Experimental / Músculo Liso Vascular Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cardiovasc Diabetol Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / ENDOCRINOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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