Growth, collapse, and stalling in a mechanical model for neurite motility.
Phys Rev E
; 93(3): 032410, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-27078393
ABSTRACT
Neurites, the long cellular protrusions that form the routes of the neuronal network, are capable of actively extending during early morphogenesis or regenerating after trauma. To perform this task, they rely on their cytoskeleton for mechanical support. In this paper, we present a three-component active gel model that describes neurites in the three robust mechanical states observed experimentally collapsed, static, and motile. These states arise from an interplay between the physical forces driven by the growth of the microtubule-rich inner core of the neurite and the acto-myosin contractility of its surrounding cortical membrane. In particular, static states appear as a mechanical balance between traction and compression of these two parallel structures. The model predicts how the response of a neurite to a towing force depends on the force magnitude and recovers the response of neurites to several drug treatments that modulate the cytoskeleton active and passive properties.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Movimento Celular
/
Neuritos
/
Fenômenos Mecânicos
/
Modelos Neurológicos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Phys Rev E
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Reino Unido