Bu Shen Tiao Chong recipe restores diminished ovary reserve through the BDNF pathway.
J Assist Reprod Genet
; 33(6): 795-805, 2016 Jun.
Article
em En
| MEDLINE
| ID: mdl-27094194
ABSTRACT
PURPOSE:
The purpose of this study was to explore the molecular pathway of BSTCR (Bu Shen Tiao Chong recipe) in retrieving diminished ovary reserve (DOR).METHODS:
The DOR model was established through injecting cyclophosphamide and the effect of BSTCR was examined under this background.RESULTS:
BSTCR was shown to restore depleted brain-derived neurotrophic factor (BDNF), CDC2, cyclin B, GSH1, and P38 levels as well as impaired oocyte maturation and the higher apoptosis induced in DOR. BSTCR also enhances the response of oocytes to in vitro fertilization, with higher implantation rate, birth rate, and placenta weight.CONCLUSION:
BSTCR might exert its beneficial role in oocyte maturation and restore DOR through regulating the BDNF pathway. And this pathway itself is probably through the consequence on several serum hormones such as FSH, E2, Inhibin B, etc.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Reserva Ovariana
/
Folículo Ovariano
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Assist Reprod Genet
Assunto da revista:
GENETICA
/
MEDICINA REPRODUTIVA
Ano de publicação:
2016
Tipo de documento:
Article