Self-Assembly Protein Nanogels for Safer Cancer Immunotherapy.

Purwada, Alberto; Tian, Ye F; Huang, Weishan; Rohrbach, Kathleen M; Deol, Simrita; August, Avery; Singh, Ankur

Purwada, Alberto; Tian, Ye F; Huang, Weishan; Rohrbach, Kathleen M; Deol, Simrita; August, Avery; Singh, Ankur.

Afiliação

Purwada A; Meinig School of Biomedical Engineering, College of Engineering, Cornell University, Ithaca, NY, 14853, USA.
Tian YF; Sibley School of Mechanical and Aerospace Engineering, College of Engineering, Cornell University, Ithaca, NY, 14853, USA.
Huang W; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.
Rohrbach KM; Department of Material Science and Engineering, College of Engineering, Cornell University, Ithaca, NY, 14853, USA.
Deol S; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.
August A; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.
Singh A; Sibley School of Mechanical and Aerospace Engineering, College of Engineering, Cornell University, Ithaca, NY, 14853, USA.

Adv Healthc Mater ; 5(12): 1413-9, 2016 06.

Article em En | MEDLINE | ID: mdl-27100566

ABSTRACT

ABSTRACT

Soluble antigen-based cancer vaccines have poor retention in tissues along with suboptimal antigen processing by dendritic cells. Multiple booster doses are often needed, leading to dose-limiting systemic toxicity. A versatile, immunomodulatory, self-assembly protein nanogel vaccine is reported that induces robust immune cell response at lower antigen doses than soluble antigens, an important step towards biomaterials-based safer immunotherapy approaches.

Assuntos

Antígenos de Neoplasias; Vacinas Anticâncer; Imunoterapia; Nanopartículas/química; Proteínas de Neoplasias; Neoplasias; Animais; Antígenos de Neoplasias/química; Antígenos de Neoplasias/imunologia; Vacinas Anticâncer/química; Vacinas Anticâncer/imunologia; Humanos; Camundongos; Proteínas de Neoplasias/química; Proteínas de Neoplasias/imunologia; Neoplasias/imunologia; Neoplasias/terapia

Palavras-chave

T cell; antigen; immunomodulation; immunotherapy; nanogels

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Anticâncer / Nanopartículas / Imunoterapia / Antígenos de Neoplasias / Proteínas de Neoplasias / Neoplasias Limite: Animals / Humans Idioma: En Revista: Adv Healthc Mater Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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