Self-Assembly Protein Nanogels for Safer Cancer Immunotherapy.
Adv Healthc Mater
; 5(12): 1413-9, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-27100566
ABSTRACT
Soluble antigen-based cancer vaccines have poor retention in tissues along with suboptimal antigen processing by dendritic cells. Multiple booster doses are often needed, leading to dose-limiting systemic toxicity. A versatile, immunomodulatory, self-assembly protein nanogel vaccine is reported that induces robust immune cell response at lower antigen doses than soluble antigens, an important step towards biomaterials-based safer immunotherapy approaches.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas Anticâncer
/
Nanopartículas
/
Imunoterapia
/
Antígenos de Neoplasias
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Proteínas de Neoplasias
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Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Adv Healthc Mater
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos