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Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA.
Gross, Andrew M; Jaeger, Philipp A; Kreisberg, Jason F; Licon, Katherine; Jepsen, Kristen L; Khosroheidari, Mahdieh; Morsey, Brenda M; Swindells, Susan; Shen, Hui; Ng, Cherie T; Flagg, Ken; Chen, Daniel; Zhang, Kang; Fox, Howard S; Ideker, Trey.
Afiliação
  • Gross AM; Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA 92093, USA; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Jaeger PA; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Kreisberg JF; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Licon K; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Jepsen KL; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Khosroheidari M; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Morsey BM; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  • Swindells S; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  • Shen H; Van Andel Research Institute, Grand Rapids, MI 49503, USA.
  • Ng CT; aTyr Pharmaceuticals, San Diego, CA 92121, USA.
  • Flagg K; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Guangzhou Kang Rui Biological
  • Chen D; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Zhang K; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Veterans Administration Healt
  • Fox HS; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address: hfox@unmc.edu.
  • Ideker T; Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA 92093, USA; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Moores Cancer
Mol Cell ; 62(2): 157-168, 2016 04 21.
Article em En | MEDLINE | ID: mdl-27105112
ABSTRACT
HIV-infected individuals are living longer on antiretroviral therapy, but many patients display signs that in some ways resemble premature aging. To investigate and quantify the impact of chronic HIV infection on aging, we report a global analysis of the whole-blood DNA methylomes of 137 HIV+ individuals under sustained therapy along with 44 matched HIV- individuals. First, we develop and validate epigenetic models of aging that are independent of blood cell composition. Using these models, we find that both chronic and recent HIV infection lead to an average aging advancement of 4.9 years, increasing expected mortality risk by 19%. In addition, sustained infection results in global deregulation of the methylome across >80,000 CpGs and specific hypomethylation of the region encoding the human leukocyte antigen locus (HLA). We find that decreased HLA methylation is predictive of lower CD4 / CD8 T cell ratio, linking molecular aging, epigenetic regulation, and disease progression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Infecções por HIV / Metilação de DNA / Epigênese Genética / Antígenos HLA Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Infecções por HIV / Metilação de DNA / Epigênese Genética / Antígenos HLA Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos