Extra-helical binding site of a glucagon receptor antagonist.

Jazayeri, Ali; Doré, Andrew S; Lamb, Daniel; Krishnamurthy, Harini; Southall, Stacey M; Baig, Asma H; Bortolato, Andrea; Koglin, Markus; Robertson, Nathan J; Errey, James C; Andrews, Stephen P; Teobald, Iryna; Brown, Alastair J H; Cooke, Robert M; Weir, Malcolm; Marshall, Fiona H

Jazayeri, Ali; Doré, Andrew S; Lamb, Daniel; Krishnamurthy, Harini; Southall, Stacey M; Baig, Asma H; Bortolato, Andrea; Koglin, Markus; Robertson, Nathan J; Errey, James C; Andrews, Stephen P; Teobald, Iryna; Brown, Alastair J H; Cooke, Robert M; Weir, Malcolm; Marshall, Fiona H.

Afiliação

Jazayeri A; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Doré AS; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Lamb D; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Krishnamurthy H; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Southall SM; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Baig AH; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Bortolato A; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Koglin M; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Robertson NJ; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Errey JC; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Andrews SP; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Teobald I; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Brown AJ; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Cooke RM; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Weir M; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.
Marshall FH; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.

Nature ; 533(7602): 274-7, 2016 05 12.

Article em En | MEDLINE | ID: mdl-27111510

Assuntos

Pirazóis/metabolismo; Receptores de Glucagon/antagonistas & inibidores; Receptores de Glucagon/química; beta-Alanina/análogos & derivados; Sítio Alostérico/efeitos dos fármacos; Cristalografia por Raios X; Glucagon/metabolismo; Glucagon/farmacologia; Humanos; Ligantes; Bicamadas Lipídicas/química; Bicamadas Lipídicas/metabolismo; Modelos Moleculares; Conformação Proteica/efeitos dos fármacos; Pirazóis/química; Pirazóis/farmacologia; Receptores de Hormônio Liberador da Corticotropina/química; Receptores de Hormônio Liberador da Corticotropina/metabolismo; Receptores de Glucagon/classificação; Receptores de Glucagon/metabolismo; beta-Alanina/química; beta-Alanina/metabolismo; beta-Alanina/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Beta-Alanina / Receptores de Glucagon Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nature Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido

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