Cereboost™, an American ginseng extract, improves cognitive function via up-regulation of choline acetyltransferase expression and neuroprotection.
Regul Toxicol Pharmacol
; 78: 53-8, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-27112419
ABSTRACT
In Alzheimer disease (AD), amyloid-beta (Aß) peptides induce the degeneration of presynaptic cholinergic system, in which decreased activity of enzyme choline acetyltransferase (ChAT) responsible for acetylcholine synthesis is observed. Cereboost™, an extract of American ginseng extract, contains a high concentration of Rb1 ginsenoside which is a well-known ingredient improving human cognitive function. We investigated the effects of Cereboost™ on learning and memory function of mice challenged with an Aß1-42 peptide and the underlying mechanisms in vitro. Cereboost™ protected against Aß1-42-induced cytotoxicity in F3.ChAT stem cells, and enhanced the ChAT gene expression. Aß1-42 injection into the mouse brain impaired the cognitive function, which was recovered by oral administration of Cereboost™. In addition, Cereboost™ restored brain microtubule-associated protein 2 and synaptophysin as well as acetylcholine concentration. The results demonstrate that Cereboost™ administration recovered the cognitive function of AD model animals by enhancing acetylcholine level via ChAT gene expression and neuroprotection.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
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Encéfalo
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Extratos Vegetais
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Acetilcolina
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Colina O-Acetiltransferase
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Cognição
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Fármacos Neuroprotetores
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Doença de Alzheimer
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Panax
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Regul Toxicol Pharmacol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Coréia do Sul