Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.
Science
; 352(6285): 565-9, 2016 Apr 29.
Article
em En
| MEDLINE
| ID: mdl-27126040
ABSTRACT
Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition. We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 61 microbial species whose abundance collectively accounted for 53% of microbial composition. Low CgA concentrations were seen in individuals with a more diverse microbiome. These results are an important step toward a better understanding of environment-diet-microbe-host interactions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Trato Gastrointestinal
/
Microbioma Gastrointestinal
Limite:
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Science
Ano de publicação:
2016
Tipo de documento:
Article