Design, synthesis, anti-tumor activity, and molecular modeling of quinazoline and pyrido[2,3-d]pyrimidine derivatives targeting epidermal growth factor receptor.

Hou, Ju; Wan, Shanhe; Wang, Guangfa; Zhang, Tingting; Li, Zhonghuang; Tian, Yuanxin; Yu, Yonghuan; Wu, Xiaoyun; Zhang, Jiajie

Hou, Ju; Wan, Shanhe; Wang, Guangfa; Zhang, Tingting; Li, Zhonghuang; Tian, Yuanxin; Yu, Yonghuan; Wu, Xiaoyun; Zhang, Jiajie.

Afiliação

Hou J; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Wan S; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Wang G; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Zhang T; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Li Z; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Tian Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Yu Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China.
Wu X; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China. Electronic address: xywugz@163.com.
Zhang J; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, PR China. Electronic address: zhangjj@smu.edu.cn.

Eur J Med Chem ; 118: 276-89, 2016 Aug 08.

Article em En | MEDLINE | ID: mdl-27132165

Assuntos

Desenho de Fármacos; Receptores ErbB/antagonistas & inibidores; Simulação de Acoplamento Molecular; Pirimidinas/síntese química; Pirimidinas/farmacologia; Quinazolinas/síntese química; Quinazolinas/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Antineoplásicos/metabolismo; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Técnicas de Química Sintética; Ensaios de Seleção de Medicamentos Antitumorais; Receptores ErbB/química; Receptores ErbB/metabolismo; Humanos; Conformação Proteica; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/química; Inibidores de Proteínas Quinases/metabolismo; Inibidores de Proteínas Quinases/farmacologia; Pirimidinas/química; Pirimidinas/metabolismo; Quinazolinas/química; Quinazolinas/metabolismo; Relação Estrutura-Atividade

Palavras-chave

Antitumor; EGFR inhibitor; Molecular docking; Molecular dynamics simulation; Quinazoline and pyrido[2,3-d]pyrimidine derivatives

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Quinazolinas / Desenho de Fármacos / Simulação de Acoplamento Molecular / Receptores ErbB Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2016 Tipo de documento: Article

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