Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.

Goode, Alice; Butler, Kevin; Long, Jed; Cavey, James; Scott, Daniel; Shaw, Barry; Sollenberger, Jill; Gell, Christopher; Johansen, Terje; Oldham, Neil J; Searle, Mark S; Layfield, Robert

Goode, Alice; Butler, Kevin; Long, Jed; Cavey, James; Scott, Daniel; Shaw, Barry; Sollenberger, Jill; Gell, Christopher; Johansen, Terje; Oldham, Neil J; Searle, Mark S; Layfield, Robert.

Afiliação

Goode A; a School of Life Sciences, University of Nottingham , Nottingham , UK.
Butler K; b School of Chemistry, University of Nottingham , Nottingham , UK.
Long J; c Centre for Biomolecular Sciences, University of Nottingham , Nottingham , UK.
Cavey J; b School of Chemistry, University of Nottingham , Nottingham , UK.
Scott D; c Centre for Biomolecular Sciences, University of Nottingham , Nottingham , UK.
Shaw B; a School of Life Sciences, University of Nottingham , Nottingham , UK.
Sollenberger J; a School of Life Sciences, University of Nottingham , Nottingham , UK.
Gell C; a School of Life Sciences, University of Nottingham , Nottingham , UK.
Johansen T; b School of Chemistry, University of Nottingham , Nottingham , UK.
Oldham NJ; c Centre for Biomolecular Sciences, University of Nottingham , Nottingham , UK.
Searle MS; a School of Life Sciences, University of Nottingham , Nottingham , UK.
Layfield R; d Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø - The Arctic University of Norway , Tromsø , Norway.

Autophagy ; 12(7): 1094-104, 2016 07 02.

Article em En | MEDLINE | ID: mdl-27158844

Assuntos

Esclerose Lateral Amiotrófica/metabolismo; Autofagia/genética; Proteínas Associadas aos Microtúbulos/metabolismo; Mutação/genética; Proteína Sequestossoma-1/genética; Esclerose Lateral Amiotrófica/genética; Esclerose Lateral Amiotrófica/patologia; Autofagia/fisiologia; Degeneração Lobar Frontotemporal; Humanos; Proteínas Associadas aos Microtúbulos/genética; Neurônios Motores/metabolismo; Neurônios Motores/patologia

Palavras-chave

ALS; Atg8/LC3; FTLD; LIR; SQSTM1/p62; autophagy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Proteína Sequestossoma-1 / Esclerose Lateral Amiotrófica / Proteínas Associadas aos Microtúbulos / Mutação Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Autophagy Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido

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