Childhood adversity and hippocampal and amygdala volumes in a population at familial high risk of schizophrenia.
Schizophr Res
; 175(1-3): 42-47, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-27179666
ABSTRACT
BACKGROUND:
There is an established link between childhood adversity (CA) and schizophrenia. Hippocampus and amygdala abnormalities pre-date onset in those at high familial risk (fHR) of schizophrenia, but it is not clear whether these alterations are associated with CA in those at elevated risk of schizophrenia.METHODS:
We examined hippocampal and amygdala volumes in those at fHR who had been referred to a social worker or the Children's Panel compared to those who had not.RESULTS:
The right hippocampus and left amygdala were significantly smaller in those that had been referred to social work and Children's Panel.CONCLUSIONS:
Our findings suggest that CA can influence structural changes in the brain in a cohort at fHR of schizophrenia. These findings provide further evidence that while genetic factors contribute to the structural changes found in schizophrenia, environmental factors such as CA can have a lasting impact on specific brain regions.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Estresse Psicológico
/
Predisposição Genética para Doença
/
Adultos Sobreviventes de Eventos Adversos na Infância
/
Hipocampo
/
Tonsila do Cerebelo
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Schizophr Res
Assunto da revista:
PSIQUIATRIA
Ano de publicação:
2016
Tipo de documento:
Article