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Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences.
Ye, Li; Allen, William E; Thompson, Kimberly R; Tian, Qiyuan; Hsueh, Brian; Ramakrishnan, Charu; Wang, Ai-Chi; Jennings, Joshua H; Adhikari, Avishek; Halpern, Casey H; Witten, Ilana B; Barth, Alison L; Luo, Liqun; McNab, Jennifer A; Deisseroth, Karl.
Afiliação
  • Ye L; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
  • Allen WE; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Neurosciences Program, Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA.
  • Thompson KR; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Tian Q; Department of Radiology, Stanford University, Stanford, CA 94305, USA.
  • Hsueh B; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Neurosciences Program, Stanford University, Stanford, CA 94305, USA.
  • Ramakrishnan C; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA.
  • Wang AC; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA.
  • Jennings JH; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA.
  • Adhikari A; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA.
  • Halpern CH; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
  • Witten IB; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Barth AL; Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  • Luo L; Department of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
  • McNab JA; Department of Radiology, Stanford University, Stanford, CA 94305, USA.
  • Deisseroth K; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Psychiatry, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic add
Cell ; 165(7): 1776-1788, 2016 Jun 16.
Article em En | MEDLINE | ID: mdl-27238022
ABSTRACT
A major challenge in understanding the cellular diversity of the brain has been linking activity during behavior with standard cellular typology. For example, it has not been possible to determine whether principal neurons in prefrontal cortex active during distinct experiences represent separable cell types, and it is not known whether these differentially active cells exert distinct causal influences on behavior. Here, we develop quantitative hydrogel-based technologies to connect activity in cells reporting on behavioral experience with measures for both brain-wide wiring and molecular phenotype. We find that positive and negative-valence experiences in prefrontal cortex are represented by cell populations that differ in their causal impact on behavior, long-range wiring, and gene expression profiles, with the major discriminant being expression of the adaptation-linked gene NPAS4. These findings illuminate cellular logic of prefrontal cortex information processing and natural adaptive behavior and may point the way to cell-type-specific understanding and treatment of disease-associated states.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Mapeamento Encefálico / Córtex Pré-Frontal Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Mapeamento Encefálico / Córtex Pré-Frontal Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos