Impact of the PROVAUR stewardship programme on linezolid resistance in a tertiary university hospital: a before-and-after interventional study.
J Antimicrob Chemother
; 71(9): 2606-11, 2016 09.
Article
em En
| MEDLINE
| ID: mdl-27246230
ABSTRACT
BACKGROUND:
There is little evidence of the impact of antimicrobial stewardship programmes on antimicrobial resistance.OBJECTIVES:
To study the efficacy and safety of a package of educational and interventional measures to optimize linezolid use and its impact on bacterial resistance.METHODS:
A quasi-experimental study was designed and carried out before and after implementation of a stewardship programme in hospitalized patients with Gram-positive infections treated with linezolid.RESULTS:
The intervention reduced linezolid consumption by 76%. The risk of linezolid-resistant CoNS isolates (ORâ=â0.37; 95% CIâ=â0.27-0.49; Pâ<â0.001) and Enterococcus faecalis (ORâ=â0.44; 95% CIâ=â0.21-0.90; Pâ=â0.03) during the intervention period was lower than in the pre-intervention period.CONCLUSIONS:
A programme to optimize linezolid use can contribute to reducing the resistance rate of CoNS and E. faecalis to this antibiotic.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Bactérias Gram-Positivas
/
Farmacorresistência Bacteriana
/
Uso de Medicamentos
/
Linezolida
/
Política de Saúde
/
Antibacterianos
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Antimicrob Chemother
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Espanha