Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy.

Sapp, Valerie; Jain, Mohit; Liao, Ronglih

Sapp, Valerie; Jain, Mohit; Liao, Ronglih.

Afiliação

Sapp V; Departments of Medicine & Pharmacology, University of California San Diego, San Diego, California; and.
Jain M; Departments of Medicine & Pharmacology, University of California San Diego, San Diego, California; and.
Liao R; Division of Genetics and Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Physiology (Bethesda) ; 31(4): 294-9, 2016 07.

Article em En | MEDLINE | ID: mdl-27252164

ABSTRACT

ABSTRACT

Proteotoxicity refers to toxic stress caused by misfolded proteins of extrinsic or intrinsic origin and plays an integral role in the pathogenesis of cardiovascular diseases. Herein, we provide an overview of the current understanding of mechanisms underlying proteotoxicity and its contribution in the pathogenesis of amyloid cardiomyopathy.

Assuntos

Proteínas Amiloidogênicas/metabolismo; Cardiomiopatias/fisiopatologia; Deficiências na Proteostase/fisiopatologia; Estresse Fisiológico; Proteínas Amiloidogênicas/toxicidade; Animais; Cardiomiopatias/metabolismo; Humanos; Deficiências na Proteostase/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Fisiológico / Deficiências na Proteostase / Proteínas Amiloidogênicas / Cardiomiopatias Limite: Animals / Humans Idioma: En Revista: Physiology (Bethesda) Assunto da revista: FISIOLOGIA Ano de publicação: 2016 Tipo de documento: Article

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