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Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial.
de la Torre, Rafael; de Sola, Susana; Hernandez, Gimena; Farré, Magí; Pujol, Jesus; Rodriguez, Joan; Espadaler, Josep María; Langohr, Klaus; Cuenca-Royo, Aida; Principe, Alessandro; Xicota, Laura; Janel, Nathalie; Catuara-Solarz, Silvina; Sanchez-Benavides, Gonzalo; Bléhaut, Henri; Dueñas-Espín, Iván; Del Hoyo, Laura; Benejam, Bessy; Blanco-Hinojo, Laura; Videla, Sebastiá; Fitó, Montserrat; Delabar, Jean Maurice; Dierssen, Mara.
Afiliação
  • de la Torre R; IMIM-Hospital del Mar Medical Research Institute and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), University Pompeu Fabra (CEXS-UPF), Barcelona, Spain.
  • de Sola S; IMIM-Hospital del Mar Medical Research Institute and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), University Pompeu Fabra (CEXS-UPF), Barcelona, Spain.
  • Hernandez G; IMIM-Hospital del Mar Medical Research Institute and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), University Pompeu Fabra (CEXS-UPF), Barcelona, Spain.
  • Farré M; IMIM-Hospital del Mar Medical Research Institute and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), University Pompeu Fabra (CEXS-UPF), Barcelona, Spain; Autonomous University of Barcelona (UDIMAS-UAB), Barcelona, Spain.
  • Pujol J; MRI Research Unit, Hospital del Mar Medical Research Institute and CIBER Mental Health (CIBERSAM G21), Barcelona, Spain.
  • Rodriguez J; IMIM-Hospital del Mar Medical Research Institute and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), University Pompeu Fabra (CEXS-UPF), Barcelona, Spain.
  • Espadaler JM; Neurofunctionality of Brain and Language Research Group-Neurosciences Program, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain.
  • Langohr K; Polytechnic University of Catalonia, Barcelona, Spain.
  • Cuenca-Royo A; IMIM-Hospital del Mar Medical Research Institute and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), University Pompeu Fabra (CEXS-UPF), Barcelona, Spain.
  • Principe A; MRI Research Unit, Hospital del Mar Medical Research Institute and CIBER Mental Health (CIBERSAM G21), Barcelona, Spain.
  • Xicota L; IMIM-Hospital del Mar Medical Research Institute and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), University Pompeu Fabra (CEXS-UPF), Barcelona, Spain.
  • Janel N; University Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, UMR 8251 CNRS, Paris, France.
  • Catuara-Solarz S; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, CIBER of Rare Diseases (CIBERER), and University Pompeu Fabra (CEXS-UPF), Barcelona, Spain.
  • Sanchez-Benavides G; IMIM-Hospital del Mar Medical Research Institute and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), University Pompeu Fabra (CEXS-UPF), Barcelona, Spain.
  • Bléhaut H; Jérôme Lejeune Foundation, Paris, France.
  • Dueñas-Espín I; IMIM-Hospital del Mar Medical Research Institute and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), University Pompeu Fabra (CEXS-UPF), Barcelona, Spain.
  • Del Hoyo L; IMIM-Hospital del Mar Medical Research Institute and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), University Pompeu Fabra (CEXS-UPF), Barcelona, Spain.
  • Benejam B; Fundació Catalana Síndrome de Down, Barcelona, Spain.
  • Blanco-Hinojo L; MRI Research Unit, Hospital del Mar Medical Research Institute and CIBER Mental Health (CIBERSAM G21), Barcelona, Spain.
  • Videla S; Fundació Catalana Síndrome de Down, Barcelona, Spain; Universitat Pompeu Fabra (DCEXS-UPF), Barcelona, Spain.
  • Fitó M; IMIM-Hospital del Mar Medical Research Institute and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), University Pompeu Fabra (CEXS-UPF), Barcelona, Spain.
  • Delabar JM; University Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, UMR 8251 CNRS, Paris, France; Inserm, U1127, CNRS, UMR 7225 ICM, 75013, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France.
  • Dierssen M; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, CIBER of Rare Diseases (CIBERER), and University Pompeu Fabra (CEXS-UPF), Barcelona, Spain. Electronic address: mara.dierssen@crg.eu.
Lancet Neurol ; 15(8): 801-810, 2016 Jul.
Article em En | MEDLINE | ID: mdl-27302362
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catequina / Terapia Cognitivo-Comportamental / Resultado do Tratamento / Síndrome de Down / Transtornos Cognitivos / Fármacos Neuroprotetores Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Lancet Neurol Assunto da revista: NEUROLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Espanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catequina / Terapia Cognitivo-Comportamental / Resultado do Tratamento / Síndrome de Down / Transtornos Cognitivos / Fármacos Neuroprotetores Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Lancet Neurol Assunto da revista: NEUROLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Espanha