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TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling.
Salazar, María; Lorente, Mar; García-Taboada, Elena; Gómez, Eduardo Pérez; Dávila, David; Zúñiga-García, Patricia; Flores, Juana M; Rodríguez, Antonio; Hegedus, Zoltan; Mosén-Ansorena, David; Aransay, Ana M; Hernández-Tiedra, Sonia; López-Valero, Israel; Quintanilla, Miguel; Sánchez, Cristina; Iovanna, Juan L; Dusetti, Nelson; Guzmán, Manuel; Francis, Sheila E; Carracedo, Arkaitz; Kiss-Toth, Endre; Velasco, Guillermo.
Afiliação
  • Salazar M; Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain.
  • Lorente M; Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain.
  • García-Taboada E; Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University ; Madrid, Spain.
  • Gómez EP; Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre (I+12); Madrid, Spain.
  • Dávila D; Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain.
  • Zúñiga-García P; CIC bioGUNE, Bizkaia Technology Park ; Derio, Spain.
  • Flores JM; Department of Animal Surgery and Medicine; School of Veterinary; Complutense University ; Madrid, Spain.
  • Rodríguez A; Department of Animal Surgery and Medicine; School of Veterinary; Complutense University ; Madrid, Spain.
  • Hegedus Z; Institute of Biophysics; Hungarian Academy of Sciences ; Szeged, Hungary.
  • Mosén-Ansorena D; CIC bioGUNE, Bizkaia Technology Park ; Derio, Spain.
  • Aransay AM; CIC bioGUNE-CIBERehd, Bizkaia Technology Park ; Derio, Spain.
  • Hernández-Tiedra S; Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain.
  • López-Valero I; Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain.
  • Quintanilla M; Instituto de Investigaciones Biomédicas Alberto Sols; Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM) ; Madrid, Spain.
  • Sánchez C; Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre (I+12); Madrid, Spain.
  • Iovanna JL; Centre de Recherche en Carcérologie de Marseille (CRCM); INSERM UMR 1068, CNRS UMR 7258, Aix Marseille Université and Institut Paoli Calmette ; Marseille, France.
  • Dusetti N; Centre de Recherche en Carcérologie de Marseille (CRCM); INSERM UMR 1068, CNRS UMR 7258, Aix Marseille Université and Institut Paoli Calmette ; Marseille, France.
  • Guzmán M; Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) and Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS); Madrid, Spain.
  • Francis SE; Department of Cardiovascular Science; University of Sheffield ; Sheffield, UK.
  • Carracedo A; CIC bioGUNE, Bizkaia Technology Park; Derio, Spain; Ikerbasque, Basque Foundation for Science; Bilbao, Spain; Biochemistry and Molecular Biology Department; University of the Basque Country (UPV/EHU); Bilbao, Spain.
  • Kiss-Toth E; Department of Cardiovascular Science; University of Sheffield ; Sheffield, UK.
  • Velasco G; Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain.
Mol Cell Oncol ; 2(3): e980134, 2015.
Article em En | MEDLINE | ID: mdl-27308456
ABSTRACT
In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Mol Cell Oncol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Espanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Mol Cell Oncol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Espanha