The role of mitochondrial DNA copy number, variants, and haplotypes in farm animal developmental outcome.
Domest Anim Endocrinol
; 56 Suppl: S133-46, 2016 07.
Article
em En
| MEDLINE
| ID: mdl-27345311
ABSTRACT
The vast majority of cellular energy is generated through the process of oxidative phosphorylation, which takes place in the electron transport chain in the mitochondria. The electron transport chain is encoded by 2 genomes, the chromosomal and the mitochondrial genomes. Mitochondrial DNA is associated with a number of traits, which include tolerance to heat, growth and physical performance, meat and milk quality, and fertility. Mitochondrial genomes can be clustered into groups known as mtDNA haplotypes. Mitochondrial DNA haplotypes are a potential genetic source for manipulating phenotypes in farm animals. The use of assisted reproductive technologies, such as nuclear transfer, allows favorable chromosomal genetic traits to be mixed and matched with sought after mtDNA haplotype traits. As a result super breeds can be generated.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Haplótipos
/
DNA Mitocondrial
/
Variações do Número de Cópias de DNA
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Gado
Limite:
Animals
Idioma:
En
Revista:
Domest Anim Endocrinol
Assunto da revista:
ENDOCRINOLOGIA
/
MEDICINA VETERINARIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Austrália