Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels.
BMC Genomics
; 17 Suppl 3: 437, 2016 06 29.
Article
em En
| MEDLINE
| ID: mdl-27357396
ABSTRACT
BACKGROUND:
CCL16 is a chemokine predominantly expressed in the liver, but is also found in the blood and brain, and is known to play important roles in immune response and angiogenesis. Little is known about the gene's regulation.METHODS:
Here, we test for potential causal SNPs that affect CCL16 protein levels in both blood plasma and cerebrospinal fluid in a genome-wide association study across two datasets. We then use METAL to performed meta-analyses with a significance threshold of p < 5x10(-8). We removed SNPs where the direction of the effect was different between the two datasets.RESULTS:
We identify 10 SNPs associated with increased CCL16 protein levels in both biological fluids.CONCLUSIONS:
Our results will help understand CCL16's regulation, allowing researchers to better understand the gene's effects on human health.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metanálise como Assunto
/
Quimiocinas CC
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Polimorfismo de Nucleotídeo Único
/
Estudo de Associação Genômica Ampla
Tipo de estudo:
Risk_factors_studies
/
Systematic_reviews
Limite:
Aged
/
Aged80
/
Humans
/
Middle aged
Idioma:
En
Revista:
BMC Genomics
Assunto da revista:
GENETICA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos