N-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp.
Chem Pharm Bull (Tokyo)
; 64(7): 766-71, 2016.
Article
em En
| MEDLINE
| ID: mdl-27373630
ABSTRACT
In the course of searching for selective growth inhibitors of the cancer cells adapted to nutrient starvation, a new 3-alkylpyridine alkaloid named N-methylniphatyne A (1) was isolated from an Indonesian marine sponge of Xestospongia sp. The chemical structure of 1 was determined on the basis of the spectroscopic analysis and comparison with the synthesized 1 and its analogues. Compound 1 showed the cytotoxic activity against PANC-1 cells under the condition of glucose starvation with IC50 value of 16 µM, whereas no growth-inhibition was observed up to 100 µM under the general culture conditions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Xestospongia
/
Alcinos
/
Antineoplásicos
Limite:
Animals
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Ano de publicação:
2016
Tipo de documento:
Article