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5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties.
Kohn, Todd J; Du, Xiaohui; Lai, SuJen; Xiong, YuMei; Komorowski, Renee; Veniant, Murielle; Fu, Zice; Jiao, Xianyun; Pattaropong, Vatee; Chow, David; Cardozo, Mario; Jin, Lixia; Conn, Marion; DeWolf, Walter E; Kraser, Christopher F; Hinklin, Ronald J; Boys, Mark L; Medina, Julio C; Houze, Jonathan; Dransfield, Paul; Coward, Peter.
Afiliação
  • Kohn TJ; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Du X; Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
  • Lai S; Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
  • Xiong Y; Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
  • Komorowski R; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Veniant M; Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Fu Z; Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
  • Jiao X; Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
  • Pattaropong V; Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
  • Chow D; Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
  • Cardozo M; Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
  • Jin L; Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
  • Conn M; Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
  • DeWolf WE; Array BioPharma Inc. , 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Kraser CF; Array BioPharma Inc. , 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Hinklin RJ; Array BioPharma Inc. , 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Boys ML; Array BioPharma Inc. , 3200 Walnut Street, Boulder, Colorado 80301, United States.
  • Medina JC; Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
  • Houze J; Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
  • Dransfield P; Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
  • Coward P; Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.
ACS Med Chem Lett ; 7(7): 666-70, 2016 Jul 14.
Article em En | MEDLINE | ID: mdl-27437074
ABSTRACT
Two 1-(4-aryl-5-alkyl-pyridin-2-yl)-3-methylurea glucokinase activators were identified with robust in vivo efficacy. These two compounds possessed higher solubilities than the previously identified triaryl compounds (i.e., AM-2394). Structure-activity relationship studies are presented along with relevant pharmacokinetic and in vivo data.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos