Angiotensin(1-7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1ß/Smad circuit.

Zhang, Li-Li; Huang, Shan; Ma, Xiao-Xin; Zhang, Wen-Yong; Wang, Dan; Jin, Si-Yi; Zhang, Yan-Ping; Li, Yang; Li, Xu

Zhang, Li-Li; Huang, Shan; Ma, Xiao-Xin; Zhang, Wen-Yong; Wang, Dan; Jin, Si-Yi; Zhang, Yan-Ping; Li, Yang; Li, Xu.

Afiliação

Zhang LL; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Huang S; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Ma XX; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Zhang WY; Department of Emergency, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Wang D; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Jin SY; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Zhang YP; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Li Y; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Li X; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious D

Free Radic Biol Med ; 97: 531-543, 2016 08.

Article em En | MEDLINE | ID: mdl-27445100

Assuntos

Angiotensina II/fisiologia; Angiotensina I/fisiologia; Transição Epitelial-Mesenquimal; Hepatócitos/fisiologia; Fragmentos de Peptídeos/fisiologia; Transdução de Sinais; Angiotensina I/farmacologia; Animais; Células Cultivadas; Colágeno Tipo I/genética; Colágeno Tipo I/metabolismo; Cadeia alfa 1 do Colágeno Tipo I; Expressão Gênica; Humanos; Peróxido de Hidrogênio/metabolismo; Inflamassomos/metabolismo; Interleucina-1beta/metabolismo; Cirrose Hepática/metabolismo; Cirrose Hepática/patologia; Masculino; Camundongos; NADPH Oxidase 4/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Fragmentos de Peptídeos/farmacologia; Ratos Wistar; Proteínas Smad/metabolismo

Palavras-chave

Angiotensin II; Angiotensin-(17); Epithelial-mesenchymal transition; Hepatocyte; Liver fibrosis; NADPH oxidase; NLRP3 inflammasome; Reactive oxygen species

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Angiotensina I / Angiotensina II / Transdução de Sinais / Hepatócitos / Transição Epitelial-Mesenquimal Limite: Animals / Humans / Male Idioma: En Revista: Free Radic Biol Med Assunto da revista: BIOQUIMICA / MEDICINA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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